Both the production organism and the enzyme produced are subject to a thorough occupational risk assessment.
Only organisms which have a long history of safe use or which have never been reported to be able to cause disease in healthy human beings are used in the production of enzymes. These organisms have been proven to be non hazardous. As for enzymes, they could however pose a certain risk to employees handling them.
Like many proteins enzymes might lead to respiratory allergy or cause some irritation when they come into direct contact with skin or eyes. These risks can be reduced by minimising the exposure, either by engineering controls (ventilation), good handling practices and personal protection measures or by using enzyme preparations which are specifically designed to minimise inhalatory exposure (e.g. liquids, encapsulated or immobilised preparations).